Allergies to mushrooms are most often associated with exposure to the mushroom spores that originate on the top part of the mushroom, called the fruit body. YS Nutrition products are derived from the mycelia, or root of the mushroom, which contains no spores. Many people who believe they are allergic to mushrooms are able to take YS Nutrition supplements with no allergic reaction. However, if you are concerned, please check with a health care professional who specializes in natural products. You should also start with a lowered dosage of the Performance-D products and if you do not experience any signs of an allergic reaction, increase the dosage until you reach the recommended daily dose.